2024

(76) Yamamoto, S., Hashidate-Yoshida, T., Yoshinari, Y., Shimizu, T., Shindou, H. Macrophage/microglia-producing transient increase of platelet-activating factor is involved in neuropathic pain. iScience 2024 in press(75) Murano, H., Inoue., S, Hashidate-Yoshida., T, Shindou, H., Shimizu, T., Otaki, Y., Minegishi, Y., Kitaoka, T., Futakuchi, M., Igarashi, A., Nishiwaki, M., Nemoto, T., Sato, M., Kobayashi, M., Sato, K., Hanawa, T., Miyazaki, O., Watanabe, M. Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via Platelet-activating Factor. Am J Respir Cell Mol Biol.2024 in press

(75) Murano, H., Inoue., S, Hashidate-Yoshida., T, Shindou, H., Shimizu, T., Otaki, Y., Minegishi, Y., Kitaoka, T., Futakuchi, M., Igarashi, A., Nishiwaki, M., Nemoto, T., Sato, M., Kobayashi, M., Sato, K., Hanawa, T., Miyazaki, O., Watanabe, M. Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via Platelet-activating Factor. Am J Respir Cell Mol Biol.2024 in press

(74) Shimura, M., Higashi-Kuwata, N., Fujiwara, A., Taniguchi, M., Ichinose, T., Hamano, F., Uematsu, M., Inoue, T., Matsuyama, S., Suzuki, T., Ghosh, AK, Shindou, H., Shimuzu, T., Mitsuya, H. A lipid index for risk of hyperlipidemia caused by anti-retroviral drugs. Antiviral Research 2024 in press

(73) Shimizu, K., Ono, M., Mikamoto, T., Urayama, Y., Yoshida, S., Hase, T., Michinaga, S., Nakanishi, H., Iwasaki, M., Terada, T., Sakurai, F., Mizuguchi, H., Shindou, H., Tomita, K., Nishinaka, T. Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose-stimulated insulin secretion. FASEB J. 2024 Jan 31;38(2):e23425. doi: 10.1096/fj.202301594RR.

(72) Inagaki, N., Nakanishi, H., Takayo Ohto, T., Shindou, H., and Shimizu, T. LPCAT3/LPLAT12 deficiency in the liver ameliorates acetaminophen-induced acute liver injury. FASEB J.  2023 Jan;38(1):e23328. doi: 10.1096/fj.202301744R.

2023

(71) Matsukawa T, Yagi T, Uchida T, Sakai M, Mitsushima M, Naganuma T, Yano H, Inaba Y, Inoue H, Yanagida K, Uematsu M, Nakao K, Nakao H, Aiba A, Nagashima Y, Kubota T, Kubota N, Izumida Y, Yahagi N, Unoki-Kubota H, Kaburagi Y, Asahara SI, Kido Y, Shindou H, Itoh M, Ogawa Y, Minami S, Terauchi Y, Tobe K, Ueki K, Kasuga M, Matsumoto M. JCI Insight. 2023 Sep 8;8(17):e161282. doi: 10.1172/jci.insight.161282. 

(70) Sato, T., Umebayashi, S., Senoo, N., Akahori, T., Ichida, H., Miyoshi, N., Yoshida, T., Sugiura, Y., Goto-Inoue, N., Kawana, H., Shindou, H., Baba, T., Maemoto, Y., Kamei, Y., Shimizu, T., Aoki, J., Miura, S. LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles. J. Biol. Chem. 2023 Jul;299(7):104848. doi: 10.1016/j.jbc.2023.104848.

 (69) Nagata, K., Kakizaki, Y., Yanagida, K., Arai, T., Nakano, K., Hamano, F., Goto, M., Okamura, T., Shimizu, T., Shindou, H.  Dietary omega-3 fatty acid does not improve male infertility caused by lysophospholipid acyltransferase 3 (LPLAT3/AGPAT3) deficiency. Biochem Biophys Res Commun. 2023 June 30;663:179-185. doi: https://doi.org/10.1016/j.bbrc.2023.04.043

 (68) Miyasato S, Iwata K, Mura R, Nakamura S, Yanagida K, Shindou H, Nagata Y, Kawahara M, Yamaguchi S, Aoki J, Inoue A, Nagamune T, Shimizu T, Nakamura M. Constitutively active GPR43 is crucial for proper leukocyte differentiation. FASEB J. 2023 Jan;37(1):e22676. doi: 10.1096/fj.202201591R.

(67)Murai, H., Kodama, T., Maesaka, K., Tange, S., Motooka, D., Suzuki, Y., Shigematsu, Y., Inamura, K., Mise, Y., Saiura, A., Ono, Y., Takahashi, Y., Kawasaki, Y., Iino, S., Kobayashi, S., Idogawa, M., Tokino, T., Hashidate-Yoshida, T., Shindou, H., Miyazaki, M., Imai, Y., Tanaka, S., Mita, E., Ohkawa, K., Hikita, H., Sakamori, R., Tatsumi, T., Eguchi, H., Morii, E., Takehara, T. Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma. Hepatology 2023 Jan 1;77(1):77-91. doi: 10.1002/hep.32573. Epub 2022 Jun 17.

2022

(66) Kawaguchi, K., Nagao, H., Shindou, H., Noguchi, H. Conformations of Three Types of Ultra-Long-Chain Fatty Acids in Multicomponent Lipid Bilayers. J Phys Chem B. 2022 Nov 17;126(45):9316-9324. doi: 10.1021/acs.jpcb.2c06189.

(65) Kawana, H., Ozawa, M., Shibata, T., Ohnishi, H., Sato, Y., Kano, K., Shindou, H., Shimizu, T., Kono, N., Aoki, J. Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase. J Lipid Res. 2022 Oct;63(10):100271. doi: 10.1016/j.jlr.2022.100271.

(64) Yamamoto, S., Hashidate-Yoshida, T., Shimizu, T., Shindou, H. Profiling of fatty acid metabolism in the dorsal root ganglion after peripheral nerve injury. Frontiers in Pain Research 2022 Jul 29;3:948689. doi: 10.3389/fpain.2022.948689. eCollection 2022.

(63) Daida, K., Shimonaka, S., Shiba-Fukushima, K., Ogata, J., Yoshino, H., Okuzumi, A., Hatano, T., Motoi, Y., Hirunagi, T., Katsuno, M., Shindou, H., Funayama, M., Nishioka, K., Hattori, N., Imai, Y. α-Synuclein V15A Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid-Binding Property. Mov Disord. 2022 Oct;37(10):2075-2085.  doi: 10.1002/mds.29162. Epub 2022 Jul 27.

(62) Nagata, K., Hishikawa, D., Sagara, H., Saito, M., Watanabe, S., Shimizu, T., and Shindou, H. Lysophosphatidylcholine acyltransferase 1 controls mitochondrial reactive oxygen species generation and survival of retinal photoreceptor cells. J. Biol. Chem. 2022 Apr 20;298(6):101958. doi: 10.1016/j.jbc.2022.101958.

(61) Tanosaki, T., Mikami, Y., Shindou, H., Suzuki, T., Hashidate-Yoshida, T., Hosoki, K., Kagawa, S., Miyata, J., Kabata, H., Masaki, K., Hamamoto, R., Kage, H., Miyashita, N., Makita, K., Matsuzaki, H., Suzuki, Y., Mitani, A., Nagase, T., Shimizu, T., Fukunaga, K. Lysophosphatidylcholine Acyltransferase 1 Deficiency Promotes Pulmonary Emphysema via Apoptosis of Alveolar Epithelial Cells. Inflammation 2022 Aug;45(4):1765-1779. doi: 10.1007/s10753-022-01659-4.

(60) Hoshino, Y., Okuno, T., Saigusa, D., Kano, K., Yamamoto, S., Shindou, H., Aoki, J., Uchida, K,, Yokomizo, T., Ito, N. Lysophosphatidic acid receptor 1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses. FASEB J. 2022 Apr;36(4):e22236. doi: 10.1096/fj.202101678R.

(59) Valentine, WJ., Mostafa, SA., Tokuoka, SM., Hamano, F., Inagaki, NF., Nordin, JZ., Motohashi, N., Kita, Y., Aoki, Y., Shimizu, T., Shindou, H. Lipidomic analyses reveal specific alterations of phosphatidylcholine in dystrophic mdx muscle. Frontiers in Physiology 2022 Jan 12;12:698166. doi: 10.3389/fphys.2021.698166.

(58) Kawai, H., Osawa, Y., Matsuda, M., Tsunoda, T., Yanagida, K., Hishikawa, D., Okawara, M., Sakamoto, Y., Shimagaki, T., Tsutsui, Y., Yoshida, Y., Yoshikawa, S., Hashi, K., Doi, H., Mori, T., Yamazoe, T., Yoshio, S., Sugiyama, M., Okuzaki, D., Komatsu, H., Inui, A., Tamura-Nakano, M., Oyama, C., Shindou, H., Kusano, H., Kage, M., Ikegami, T., Yanaga, K., Kanto, T. Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy. Hepatology 2022 Jul;76(1):112-125. doi: 10.1002/hep.32256.

2021

(57) Senoo, N., Akahori, T., Ichida, H., Miyoshi, N., Morita, A., Shimizu, T., Shindou, H., Miura, S. Fasting increases 18:2-containing phosphatidylcholines to complement the decrease in 22:6-containing phosphatidylcholines in mouse skeletal muscle. PLoS One 2021 Jul 26;16(7):e0255178. doi: 10.1371/journal.pone.0255178.

(56) Kobayashi, A., Ito, A., Shirakawa, I., Tamura, A., Tomono, S., Shindou, H., Hedde, PN., Tanaka, M., Tsuboi, N., Ishimoto, T., Akashi-Takamura, S., Maruyama, S., Suganami, T. Dietary supplementation with eicosapentaenoic acid inhibits plasma cell differentiation and attenuates lupus autoimmunity. Frontiers in Immunology 2021 Jun 15;12:650856. doi: 10.3389/fimmu.2021.650856.

(55) Hamano, F., Matoba, K., Hashidate-Yoshida, T., Suzuki, T., Miura, K., Hishikawa, D., Harayama, T., Yuki, K., Kita, Y., Noda, N., Shimizu, T., Shindou, H. Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA. FASEB J. 2021 35(6):e21501. doi: 10.1096/fj.202002591R.

(54) Hamano, F., Kuribayashi, H., Iwagawa, T., Tsuhako, A., Nagata, K., Sagara, H., Shimizu, T., Shindou, H., and Watanabe, S. Mapping membrane lipids in the developing and adult mouse retina under physiological and pathological conditions using mass spectrometry. J. Biol. Chem. 2021 16;296:100303. doi: 10.1016/j.jbc.2021.100303.

2020

(53) Kawaguchi, K., Nakagawa, K., Nakagawa, S., Shindou, H., Nagao, H., and Noguchi, H. Conformation of ultra-long-chain fatty acid in lipid bilayer: Molecular dynamics study. J Chem Phys. 2020 Oct 28;153(16):165101.

(52) Hishikawa, D., Yanagida, K., Nagata, K., Kanatani, A., Iizuka, Y., Hamano, F., Yasuda, M., Okamura, T., Shindou, H., Shimizu, T. Hepatic levels of DHA-containing phospholipids instruct SREBP1-mediated synthesis and systemic delivery of polyunsaturated fatty acids.iScience 2020 Aug 22;23(9):101495.

(51) Uematsu, M., Kita, Y., Shimizu, T., Shindou, H. Multiplex fatty acid imaging inside cells by Raman microscopy. FASEB J. 2020 Aug;34(8):10357-10372.

(50) Hamano, F., Tokuoka, M. S., Yoshida, H. T., Shindou, H., Shimizu, T., and Kita, Y. Quantification of Fatty Acids in Mammalian Tissues by Gas Chromatography–Hydrogen Flame Ionization Detection. Bio-protocol 2020 10(09): e3613. DOI:10.21769/BioProtoc.3613

(49) Eto, M., Shindou, H., Yamamoto, S., Tamura-Nakano, M., Shimizu, T. Lysophosphatidylethanolamine acyltransferase 2 (LPEAT2) incorporates DHA into phospholipids and has possible functions for fatty acid-induced cell death. Biochem Biophys Res Commun. 2020 May 21;526(1):246-252. doi: 10.1016/j.bbrc.2020.03.074.

2019

(48) Mori, A., Hatano, T., Inoshita, T., Shiba-Fukushima, K., Koinuma, T., Meng, H., Kudo, S., Spratt, S., Cui, C., Yamashita, C., Miki, Y., Yamamoto, K., Hirabayashi, T., Murakami, M., Takahashi, Y., Shindou, H., Nonaka, T., Hasegawa, M., Okuzumi, A., Imai, Y., Hattori, N. Parkinson's disease-associated iPLA2-VIA/ PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20689-20699.

(47) Kobayashi H, Morikawa T, Okinaga A, Hamano F, Hashidate-Yoshida T, Watanuki S, Hishikawa D, Shindou H, Arai F, Kabe Y, Suematsu M, Shimizu T, Takubo K. Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell Reports 2019 Jul 2;28(1):145-158.e9.

(46) Kawana H, Kano K, Shindou H, Inoue A, Shimizu T, Aoki J. An accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1053-1060.

2018

(45) Valentine WJ, Tokuoka SM, Hishikawa D, Kita Y, Shindou H, Shimizu T. Lysophosphatidic Acid Acyltransferase 3 Incorporates Docosahexaeneoic Acid into Skeletal Muscle Cell Membranes and Is Upregulated by PPARδ Activation. J Lipid Res. 2018 Feb;59(2):184-194.

2017

(44) Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Shimizu T, Okinaga T, Seta Y, Tominaga K, Nishihara T. Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells. Sci Rep. 2017 Dec 1;7(1):16701. doi: 10.1038/s41598-017-16902-4.

(43) Kimura H, Suzuki M, Konno S, Shindou H, Shimizu T, Nagase T, Miyazaki T, Nishimura M. Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury. J Immunol. 2017 Dec 1;199(11):3870-3882.

(42) Iizuka-Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, Nakanishi H, Shindou H, Okamura T, Ito C, Toshimori K, Sasaki T, Shimizu T. Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J Biol Chem. 2017 Jul 21;292(29):12065-12076.

(41) Shindou H, Koso H, Sasaki J, Nakanishi H, Sagara H, Nakagawa KM, Takahashi Y, Hishikawa D, Iizuka-Hishikawa Y, Tokumasu F, Noguchi H, Watanabe S, Sasaki T, Shimizu T. Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J Biol Chem. 2017 Jul 21;292(29):12054-12064. 　　　　　　　*Featured in “Research Highlights” on the FEBS Journal

(40) Shindou H, Shiraishi S, Tokuoka SM, Takahashi Y, Harayama T, Abe T, Bando K, Miyano K, Kita Y, Uezono Y, Shimizu T. Relief from neuropathic pain by blocking of platelet-activating factor-pain loop. FASEB J. 2017 Jul;31(7):2973-2980.

2016

(39) Shigematsu M, Koga T, Ishimori A, Saeki K, Ishii Y, Taketomi Y, Ohba M, Jo-Watanabe A, Okuno T, Harada N, Harayama T, Shindou H, Li JD, Murakami M, Hoka S, Yokomizo T. Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury. Sci Rep. 2016 Oct 5;6:34560. doi: 10.1038/srep34560.

(38) Doi H, Sato K, Shindou H, Sumi K, Koyama H, Hosoya T, Watanabe Y, Ishii S, Tsukada H, Nakanishi K, Suzuki M. Blood–brain barrier permeability of ginkgolide: Comparison of the behavior of PET probes 7a-[18F]fluoro- and 10-O-p-[11C]methylbenzyl ginkgolide B in monkey and rat brains. Bioorg Med Chem. 2016 Nov 1;24(21):5148-5157.

(37) Shimura M*, Shindou H*, Szyrwiel L*, Tokuoka SM, Hamano F, Matsuyama S, Okamoto M, Matsunaga A, Kita Y, Ishizaka Y, Yamauchi K, Kohmura Y, Lobinski R, Shimizu I, Shimizu T. Imaging of Intracellular Fatty Acids by Scanning X-ray Fluorescence Microscopy. FASEB J. 2016 Dec;30(12):4149-4158.

*, equal contribution

(36) Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Okinaga T, Shimizu T, Tominaga K, Nishihara T. Lysophosphatidylethanolamine acyltransferase 1/membrane bound O-acyltransferase 1 regulates morphology and function of P19C6 cell-derived neurons. FASEB J. 2016 Jul;30(7):2591-601.

(35) Akagi S, Kono N, Ariyama H, Shindou H, Shimizu T, Arai H. Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids. FASEB J. 2016 May;30(5):2027-39.

2015

(34) Harayama T, Shindou H, Kita Y, Otsubo E, Ikeda K, Chida S, Weaver TE, Shimizu T. Establishment of LC-MS method for the analysis of palmitoylated surfactant proteins. J Lipid Res. 2015 Jul;56(7):1370-9.

(33) Taniguchi K, Hikiji H, Okinaga T, Hashidate-Yoshida T, Shindou H, Ariyoshi W, Shimizu T, Tominaga K, Nishihara T. Essential Role of Lysophosphatidylcholine Acyltransferase 3 in the Induction of Macrophage Polarization in PMA-Treated U937 Cells. J Cell Biochem.2015 Dec;116(12):2840-8.

(32) Hashidate-Yoshida T, Harayama T, Hishikawa D, Morimoto R, Hamano F, Tokuoka SM, Eto M, Tamura-Nakano M, Yanobu-Takanashi R, Mukumoto Y, Kiyonari H, Okamura T, Kita Y, Shindou H, Shimizu T. Fatty acyl-chain remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. Elife 2015 Apr 21;4. doi: 10.7554/eLife.06328.

(31) Koeberle A, Pergola C, Shindou H, Koeberle SC, Shimizu T, Laufer SA, Werz O. Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis. FASEB J. 2015 Jun;29(6):2439-49.

2014

(30) Tarui M, Shindou H, Kumagai K, Morimoto R, Harayama T, Hashidate T, Kojima H, Okabe T, Nagano T, Nagase T, Shimizu T. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. J Lipid Res. 2014 Jul;55(7):1386-96.

(29) Harayama T, Eto M, Shindou H, Kita Y, Otsubo E, Hishikawa D, Ishii S, Sakimura K, Mishina M, Shimizu T. Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo. Cell Metab. 2014 Aug 5;20(2):295-305.

(28) Morimoto R, Shindou H, Tarui M, Shimizu T. Rapid Production of Platelet-activating Factor Is Induced by Protein Kinase Cα-mediated Phosphorylation of Lysophosphatidylcholine Acyltransferase 2. J Biol Chem. 2014 May 30;289(22):15566-76.

(27) Eto M, Shindou H, Shimizu T. A Novel Lysophosphatidic Acid Acyltransferase Enzyme (LPAAT4) with a Possible Role for Incorporating Docosahexaenoic Acid into Brain Glycerophospholipids. Biochem Biophys Res Commun. 2014 Jan 10;443(2):718-24.

2013

(26) Hishikawa D, Shindou H, Harayama T, Ogasawara R, Suwabe A, Shimizu T. Identification of Sec14-like 3 as a novel lipid-packing sensor in the lung. FASEB J. 2013 Dec;27(12):5131-40.

(25) Tokuoka SM, Kita Y, Shindou H, Shimizu T. Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. Biochem Biophys Res Commun. 2013 Jun 28;436(2):306-12.

(24) Koeberle A, Shindou H, Koeberle SC, Laufer SA, Shimizu T, Werz O. Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2546-51.

2012

(23) Eto M, Shindou H, Koeberle A, Harayama T, Yanagida K, Shimizu T. Lysophosphatidylcholine acyltransferase 3 is the key enzyme for incorporating arachidonic acid into glycerophospholipids during adipocyte differentiation. Int J Mol Sci. 2012 Dec 3;13(12):16267-80.

(22) Koeberle A, Shindou H, Harayama T, Shimizu T. Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol. J Biol Chem. 2012 Aug 3;287(32):27244-54.

(21) Koeberle A, Shindou H, Harayama T, Yuki K, Shimizu T. Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. FASEB J. 2012 Jan;26(1):169-80.

2010

(20) Koeberle A, Shindou H, Harayama T, Shimizu T. Role of lysophosphatidic acid acyltransferase 3 for the supply of highly polyunsaturated fatty acids in TM4 Sertoli cells. FASEB J. 2010 Dec;24(12):4929-38.

(19) Morimoto R, Shindou H, Oda Y, Shimizu T. Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages. J Biol Chem. 2010 Sep 24;285(39):29857-62.

(18) Ma J, Altomare A, de la Monte S, Tong M, Rieder F, Fiocchi C, Behar J, Shindou H, Biancani P, Harnett KM. HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G791-8.

2009

(17) Harayama T, Shindou H, Shimizu T. Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1. J Lipid Res. 2009 Sep;50(9):1824-31.

(16) Shindou H, Eto M, Morimoto R, Shimizu T. Identification of membrane O-acyltransferase family motifs. Biochem Biophys Res Commun. 2009 Jun 5;383(3):320-5.

(15) Yuki K, Shindou H, Hishikawa D, Shimizu T. Characterization of mouse lysophosphatidic acid acyltransferase 3: An enzyme with dual functions in the testis. J Lipid Res. 2009 May;50(5):860-9.

2008

(14) Kihara Y, Yanagida K, Masago K, Kita Y, Hishikawa D, Shindou H, Ishii S, Shimizu T. Platelet-Activating Factor Production in the Spinal Cord of Experimental Allergic Encephalomyelitis Mice via the Group IVA Cytosolic PLA2-LysoPAFAT Axis. J Immunol. 2008 Oct 1;181(7):5008-14.

(13) Harayama T*, Shindou H* (*, equal contribution), Ogasawara R, Suwabe A, Shimizu T. Identification of a novel non-inflammatory biosynthetic pathway of platelet-activating factor. J Biol Chem. 2008 Apr 25;283(17):11097-106.

(12) Tsujimura Y, Obata K, Mukai K, Shindou H, Yoshida M, Nishikado H, Kawano Y, Minegishi Y, Shimizu T, Karasuyama H. Basophils play a pivotal role in IgG- but not IgE-mediated systemic anaphylaxis in contrast to mast cells. Immunity 2008 Apr;28(4):581-9.

(11) Hishikawa D*, Shindou H* (*, equal contribution), Kobayashi S, Nakanishi H, Taguchi R, Shimizu T. Discovery of a novel lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2830-5.

2007

(10) Shindou H, Hishikawa D, Nakanishi H, Harayama T, Ishii S, Taguchi R, Shimizu T. A single enzyme catalyzes both PAF production and membrane biogenesis of inflammatory cells: cloning and characterization of acetyl-CoA:lyso-PAF acetyltransferase. J Biol Chem.2007 Mar 2;282(9):6532-9.

2006

(9) Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T. Cloning and characterization of mouse lung-type acyl-coa:lysophosphatidylcholine acyltransferase 1 (LPCAT1): Expression in alveolar type II cells, and possible involvement in surfactant production. J Biol Chem. 2006 Jul 21;281(29):20140-7.

2005

(8) Shindou H, Ishii S, Yamamoto M, Takeda K, Akira S, Shimizu T. Priming Effect of Lipopolysaccharide on Acetyl-Coenzyme A: Lyso-Platelet-Activating Factor Acetyltransferase Is MyD88 and TRIF Independent. J Immunol. 2005 Jul 15;175(2):1177-83.

2004

(7) Hikiji H, Ishii S, Shindou H, Takato T, Shimizu T. Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. J Clin Invest. 2004 Jul;114(1):85-93.

(6) Ishii S, Nagase T, Shindou H, Takizawa H, Ouchi Y, Shimizu T. Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. J Immunol. 2004 Jun 1;172(11):7095-102.

2003

(5) Vogensen SB, Strømgaard K, Shindou H, Jaracz S, Suehiro M, Ishii S, Shimizu T, Nakanishi K. Preparation of 7-substituted ginkgolide derivatives: potent platelet-activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8.

2002

(4) Strømgaard K, Saito DR, Shindou H, Ishii S, Shimizu T, Nakanishi K. Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation. J Med Chem. 2002 Aug 29;45(18):4038-46.

(3) Nagase T, Ishii S, Shindou H, Ouchi Y, Shimizu T. Airway hyperresponsiveness in transgenic mice overexpressing platelet-activating factor receptor is mediated via an atropine sensitive pathway. Am J Respir Crit Care Med. 2002 Jan 15;165(2):200-5.

2000

(2) Shindou H, Ishii S, Uozumi N, Shimizu T. Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. Biochem Biophys Res Commun. 2000 May 19;271(3):812-7.

1998

(1) Ohguro H, Yoshida N, Shindou H, Crabb JW, Palczewski K, Tsuda M. Identification of a Single Phosphorylation Site Within Octopus Rhodopsin. Photochem Photobiol. 1998 Dec;68(6):824-8.